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Jiayue Li, Le Bo, Pengjie Zhang, Qinqin Gao, Lingjun Li, Jiaqi Tang, Chonglong Wu, Dawei Li, Jianping Xiao, Jie Chen, Jianying Tao, Caiping Mao, Zhice Xu, Exposure to Nicotine During Pregnancy and Altered Learning and Memory in the Rat Offspring, Nicotine & Tobacco Research, Volume 17, Issue 6, June 2015, Pages 661–666, https://doi.org/10.1093/ntr/ntu178
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Abstract
Prenatal exposure to nicotine can cause many fetal developmental problems. This study determined the influence of nicotine during pregnancy on the development of cognitive behavior in the offspring.
Nicotine was administered to pregnant rats through implanted osmotic mini-pumps at 6mg/kg/day and flow rate of 60 μl/day for whole pregnancy from gestational day 4. Fetal and offspring body and brain weight was measured. Learning and memory were tested in adult offspring with Morris water maze; Learning and memory-related receptors were measured.
The results showed that exposure to prenatal nicotine (PN) not only caused fetal growth restriction, but also had long-term effects on learning and memory in the offspring. The PN offspring exhibited longer escape latency regardless of sex. The number of passing the platform was significantly less in the PN offspring than that of the control. The expression of messenger RNA (mRNA) and protein of N -methyl- D -aspartic acid receptor (NMDAR) in the hippocampus was significantly increased, whereas alpha7 nicotinic acetylcholine receptor (α 7 nAChR) protein was decreased with unchanged α 7 nAChR mRNA in the PN offspring.
The data provided novel information on the PN-affected development in learning and memory in the offspring, suggesting that α 7 nAChR and NMDAR1 in the hippocampus might be the targets for actions of PN in association with memory impairment.
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